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Clomid for men
(Clomiphene/Serophene)

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Clomid ®

Brand names: Clomid ®, Serophene ®

Active ingredient: Clomiphene

Clomid is a very effective drug to increase the secretion of LH (Luteinizing hormone).
In Men, LH is responsible for the production of testosterone (the male hormone) by the leydig cells of the testes.

Clomid is used in men that have low testosterone levels and those who have low sperm count.

Clomid is also widely used among athletes and bodybuilders who abuse anabolic steroids, hormones and other performance enhancing substances. In these individuals, Clomid may have a profound effect as Post Cycle Therapy (PCT) in encouraging the body to produce testosterone naturally. Even short term use of steroids for several weeks have been shown in medical studies to suppress the body's own natural production of testosterone.

Clomid is known to be used in men for the following conditions:

  • Men with low natural testosterone production
    Clomid will increase natural testosterone production

  • Men with azoospermia - Low or lack of sperm production
    Clomid will increase sperm production

  • Men with poor motility sperm - Sperm count may be fine but they may have inability to travel to the egg
    Clomid may improve motility and sperm quality

  • Men on Testosterone therapy who have testicular shrinkage
    Clomid will help bring back "the boys"

  • Athletes and bodybuilders who have a low testosterone and sperm production as a result banned substances abuse
    Clomid will assist in the body to produce testosterone and sperm

It may also be used for other conditions as determined by a doctor.
As with every medicine, Clomid can also have side effects
You must always consult with a licensed physician before using Clomid

Many medical studies by reputable medical centers and universities have found Clomid very effective for men.

Below are some extracts from medical studies and research about the effectivness of Clomid in men :


This study was made on 36 men with a low testosterone production.
They were given just 25mg/day of Clomid (half a pill a day).

After just 4-6 weeks the testosterone in the men more than doubled itself.
Testosterone increased from 248 ng/dl before treatment to 610 ng/ml after treatment.

Article published on British Journal of Sexual Medicine, 2005 Sep
Section of Adolescent Medicine, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100 Ankara-Turkey
AIM: Symptomatic late-onset hypogonadism is associated not only with a decline in serum testosterone, but also with a rise in serum estradiol. These endocrine changes negatively affect libido, sexual function, mood, behavior, lean body mass, and bone density. Currently, the most common treatment is exogenous testosterone therapy. This treatment can be associated with skin irritation, gynecomastia, nipple tenderness, testicular atrophy, and decline in sperm counts. In this study we investigated the efficacy of clomiphene citrate in the treatment of hypogonadism with the objectives of raising endogenous serum testosterone (T) and improving the testosterone/estrogen (T/E) ratio. METHODS: Our cohort consisted of 36 Caucasian men with hypogonadism defined as serum testosterone level less than 300 ng/dL. Each patient was treated with a daily dose of 25 mg clomiphene citrate and followed prospectively. Analysis of baseline and follow-up serum levels of testosterone and estradiol levels were performed. RESULTS: The mean age was 39 years, and the mean pretreatment testosterone and estrogen levels were 247.6 +/- 39.8 ng/dL and 32.3 +/- 10.9, respectively. By the first follow-up visit (4-6 weeks), the mean testosterone level rose to 610.0 +/- 178.6 ng/dL (P < 0.00001). Moreover, the T/E ratio improved from 8.7 to 14.2 (P < 0.001). There were no side effects reported by the patients. CONCLUSIONS: Low dose clomiphene citrate is effective in elevating serum testosterone levels and improving the testosterone/estradiol ratio in men with hypogonadism. This therapy represents an alternative to testosterone therapy by stimulating the endogenous androgen production pathway.
Link to original article on pubmed


Select patients with hypogonadotropic hypogonadism may respond to
treatment with clomiphene citrate (Clomid)


Article published on Fertility and Sterility, 2006 Sep
Department of Urology, NY Presbyterian Medical Center, New York, NY, USA.
OBJECTIVE: To review the management of male hypogonadotropic hypogonadism (HH) and evaluate the efficacy of clomiphene citrate (CC). DESIGN: Retrospective review. SETTING: Two university-based urology clinics. PATIENT(S): Ten patients referred for male infertility evaluation. INTERVENTION(S): Patients were treated with either clomiphene citrate or injectable gonadotropins. MAIN OUTCOME MEASURE(S): Changes in seminal parameters, gonadotropin levels, serum testosterone, and pregnancy. RESULT(S): Ten men who were evaluated for infertility were diagnosed with HH. Four had Kallmann's syndrome, four idiopathic HH, and two panhypopituitarism. Eight patients were azoospermic, and two were oligospermic on presentation. Three of the four men with adult-onset idiopathic HH responded to CC alone with increases in testosterone, FSH, and LH. Semen parameters in this group also improved, and two of the three men achieved pregnancies with CC alone. Out of the ten men actively attempting conception, four pregnancies were achieved. Three pregnancies (two with CC and one with gonadotropins) were in men diagnosed with adult-onset idiopathic forms of HH. CONCLUSION(S): Select patients with adult-onset idiopathic forms of HH may benefit from a trial of clomiphene citrate.
Link to original article on pubmed


Clomiphene (Clomid) administration for cases of nonobstructive
azoospermia: a multicenter study.


Article published on Asian Journal of Andrology, 2005 Nov-Dec
Minia Infertiflity Research and Treatment Unit, El-Minia University, Egypt.
Clomiphene citrate is a well-established agent that has been empirically used in cases of idiopathic oligospermia. Clomiphene increases endogenous gonadotropin-releasing hormone secretion from the hypothalamus and gonadotropin hormone secretion directly from the pituitary and, thus, increases intratesticular testosterone concentration. Using intracytoplasmic sperm injection (ICSI), very few sperm may be required for fertilization. The objective of this study was to determine if the application of clomiphene citrate in males with nonobstructive azoospermia might produce sufficient sperm for ICSI, either by resulting in sperm identified in the ejaculate or by potentially improving outcomes of surgical testicular sperm extraction. Forty-two patients with nonobstructive azoospermia (age range, 25-39 years) from 3 international centers were evaluated with routine history, physical examination, and hormonal assessment. Initial testicular biopsy demonstrated maturation arrest in 42.9% and hypospermatogenesis in 57.1% of patients. Clomiphene citrate was administered, with the dose titrated to achieve serum testosterone levels between 600 ng/dL and 800 ng/dL, and semen analyses were performed at periodic intervals. In patients remaining azoospermic on semen analysis, surgical testicular biopsy and sperm extraction were performed. After clomiphene citrate therapy, 64.3% of the patients demonstrated sperm in their semen analyses ranging from 1 to 16 million sperm/mL, with a mean sperm density of 3.8 million/mL. Sufficient sperm for ICSI was retrieved by testicular sperm extraction in all patients, even though 35.7% remained azoospermic. Additionally, clomiphene citrate administration resulted in a statistically significant increase in testis biopsy patterns associated with greater likelihood of sperm obtained by surgical extraction (P < .05). We conclude that clomiphene citrate administration may result in sperm in the ejaculate of patients with nonobstructive azoospermia or the simplification of testis sperm retrieval. Surgeons may consider a course of clomiphene citrate administration prior to surgical sperm retrieval in patients with nonobstructive azoospermia.
Link to original article on pubmed


Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: who does and does not benefit?

Article published on International journal of impotence research, 2003 June 1986
Center for Sexual Function (Endocrinology), Peabody, Massachusetts 01960, USA
Secondary hypogonadism is more common than primary gonadal failure and is seen in chronic and acute illnesses. Although testosterone has a role in erections, its importance in erectile dysfunction (ED) has been controversial. Hypogonadism produced by functional suppression of pituitary gonadotropins has been shown to correct with clomiphene citrate, but with a modest effect on sexual function. We wondered if longer treatment would produce improved results. A total of 178 men with secondary hypogonadism and ED received clomiphene citrate for 4 months. Sexual function improved in 75%, with no change in 25%, while significant increases in luteinizing hormone (P<0.001) and free testosterone (P<0.001) occurred in all patients.Multivariable analysis showed that responses decreased significantly with aging (P<0.05). Decreased responses also occurred in men with diabetes, hypertension, coronary artery disease, and multiple medication use. Since these conditions are more prevalent with aging, chronic disease may be a more important determinant of sexual dysfunction. Men with anxiety-related disorders responded better to normalization of testosterone. Assessment of androgen status should be accomplished in all men with ED. For those with lower than normal age-matched levels of testosterone treatment directed at normalizing testosterone with clomiphene citrate is a viable alternative to giving androgen supplements.
Link to original article on pubmed

ALWAYS CONSULT WITH YOUR DOCTOR BEFORE USING CLOMID

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THE INFORMATION PRESENTED HERE IS FOR ENTERTAINMENT PURPOSES ONLY. IT WAS NOT WRITTEN BY MEDICAL PROFESSIONALS. THIS INFORMATION MAY NOT SERVE AS ANY KIND OF BASIS FOR MEDICAL EVALUATION OR ANY OTHER MEDICAL ISSUE WHATSOEVER. ONLY USE CLOMID AS INSTRUCTED BY A LICENSED DOCTOR.


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