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Clomid ®
Generics: Gonaphene ®, Serophene ®, Klomen ®

Active ingredient: Clomiphene

Clomid is a very effective medicine for both men and women. Often referred to as the "fertility pill" for women, Clomid improves the stimulation of developing follicles (eggs) in the ovaries. Clomid is an estrogen agonist/antagonist, it's effective for being an antagonist in breast tissues as well as having a marked effect on the hypothalamus (HPTA). 60-80% of women treated with Clomid will ovulate normally, with half being able to become pregnant.

In women Clomid is used as a fertility drug.

In men Clomid has been proven very effective for promoting the secretion of LH (Luteinizing hormone). LH is responsible in men for the production of testosterone (the male hormone) by the leydig cells of the testes.

Clomid is used in men that have low testosterone levels and those who have low sperm count.
Clomid is also widely used among athletes and bodybuilders who abuse anabolic steroids, hormones and other performance enhancing substances. In these individuals, Clomid may have a profound effect as Post Cycle Therapy (PCT) in encouraging the body to produce testosterone naturally. Even short term use of steroids for several weeks have been shown in medical studies to suppress the body's own natural production of testosterone.

Clomid may be used alone or in conjunction with HCG. There are many different protocols out there and it is important to stress than only a licensed doctor can give directions for individuals use. You may wish to consult with an endocrinologist who worked with athletes before, they have much more experience.

The regimen in which Clomid should be used depends on the individual condition, how long has he been using steroids and if HCG was used mid-cycle or not.

Some common Clomid regimen include:
  • Clomid 100mg (1 tab morning + 1 tab night) taken for 3 weeks, followed by another 3 weeks in which only 50mg (one tablet) of Clomid is taken. Most start Clomid use 3-6 days after the cycle is over. That allows Clomid to start working and overlap with exogenous testosterone that is still in the body. Bodybuilders who decided to wait 3 weeks or longer after the cycle to start Clomid may feel a "crash". That's the reason so many switch to start using it a few days after the cycle is over.

  • Some advocate the additional use of HCG during the first 3 weeks of Clomid usage, at about 1500iu taken 3 times a week. In that case, Clomid is taken 100mg for the first 3 weeks, along with Monday / Wednesday / Friday injections of HCG (1000iu to 2500iu each) done for the first 3 weeks. The next 3 weeks are followed with 50mg of Clomid a day, in hope to achieve a synergistic effect with Clomid and/or HCG.

  • Many medical studies show Nolvadex is also effective in increasing LH levels, as it works quite similar to the way Clomid works. For that reason, some add 10mg to 20mg of Nolvadex daily to their post cycle therapy.

There is quite an extensive medical research done about Clomid (Clomiphene) and it's use in both men and women. Some quoted studies of particular interest are listed below.

Article medical research extract:
Select patients with hypogonadotropic hypogonadism may respond to
treatment with clomiphene citrate (Clomid)

Article published on Fertility and Sterility, 2006 Sep
Department of Urology, NY Presbyterian Medical Center, New York, NY, USA.
OBJECTIVE: To review the management of male hypogonadotropic hypogonadism (HH) and evaluate the efficacy of clomiphene citrate (CC). DESIGN: Retrospective review. SETTING: Two university-based urology clinics. PATIENT(S): Ten patients referred for male infertility evaluation. INTERVENTION(S): Patients were treated with either clomiphene citrate or injectable gonadotropins. MAIN OUTCOME MEASURE(S): Changes in seminal parameters, gonadotropin levels, serum testosterone, and pregnancy. RESULT(S): Ten men who were evaluated for infertility were diagnosed with HH. Four had Kallmann's syndrome, four idiopathic HH, and two panhypopituitarism. Eight patients were azoospermic, and two were oligospermic on presentation. Three of the four men with adult-onset idiopathic HH responded to CC alone with increases in testosterone, FSH, and LH. Semen parameters in this group also improved, and two of the three men achieved pregnancies with CC alone. Out of the ten men actively attempting conception, four pregnancies were achieved. Three pregnancies (two with CC and one with gonadotropins) were in men diagnosed with adult-onset idiopathic forms of HH. CONCLUSION(S): Select patients with adult-onset idiopathic forms of HH may benefit from a trial of clomiphene citrate.
Link to original article on pubmed

Article medical research extract:
Clomiphene citrate (Clomid) effects on testosterone/estrogen ratio in male hypogonadism.
Article published on British Journal of Sexual Medicine, 2005 Sep
Section of Adolescent Medicine, Department of Pediatrics, Hacettepe University Faculty of Medicine, 06100 Ankara-Turkey
AIM: Symptomatic late-onset hypogonadism is associated not only with a decline in serum testosterone, but also with a rise in serum estradiol. These endocrine changes negatively affect libido, sexual function, mood, behavior, lean body mass, and bone density. Currently, the most common treatment is exogenous testosterone therapy. This treatment can be associated with skin irritation, gynecomastia, nipple tenderness, testicular atrophy, and decline in sperm counts. In this study we investigated the efficacy of clomiphene citrate in the treatment of hypogonadism with the objectives of raising endogenous serum testosterone (T) and improving the testosterone/estrogen (T/E) ratio. METHODS: Our cohort consisted of 36 Caucasian men with hypogonadism defined as serum testosterone level less than 300 ng/dL. Each patient was treated with a daily dose of 25 mg clomiphene citrate and followed prospectively. Analysis of baseline and follow-up serum levels of testosterone and estradiol levels were performed. RESULTS: The mean age was 39 years, and the mean pretreatment testosterone and estrogen levels were 247.6 +/- 39.8 ng/dL and 32.3 +/- 10.9, respectively. By the first follow-up visit (4-6 weeks), the mean testosterone level rose to 610.0 +/- 178.6 ng/dL (P < 0.00001). Moreover, the T/E ratio improved from 8.7 to 14.2 (P < 0.001). There were no side effects reported by the patients. CONCLUSIONS: Low dose clomiphene citrate is effective in elevating serum testosterone levels and improving the testosterone/estradiol ratio in men with hypogonadism. This therapy represents an alternative to testosterone therapy by stimulating the endogenous androgen production pathway.
Link to original article on pubmed

Article medical research extract:
Clomiphene (Clomid) administration for cases of nonobstructive
azoospermia: a multicenter study.

Article published on Asian Journal of Andrology, 2005 Nov-Dec
Minia Infertiflity Research and Treatment Unit, El-Minia University, Egypt.
Clomiphene citrate is a well-established agent that has been empirically used in cases of idiopathic oligospermia. Clomiphene increases endogenous gonadotropin-releasing hormone secretion from the hypothalamus and gonadotropin hormone secretion directly from the pituitary and, thus, increases intratesticular testosterone concentration. Using intracytoplasmic sperm injection (ICSI), very few sperm may be required for fertilization. The objective of this study was to determine if the application of clomiphene citrate in males with nonobstructive azoospermia might produce sufficient sperm for ICSI, either by resulting in sperm identified in the ejaculate or by potentially improving outcomes of surgical testicular sperm extraction. Forty-two patients with nonobstructive azoospermia (age range, 25-39 years) from 3 international centers were evaluated with routine history, physical examination, and hormonal assessment. Initial testicular biopsy demonstrated maturation arrest in 42.9% and hypospermatogenesis in 57.1% of patients. Clomiphene citrate was administered, with the dose titrated to achieve serum testosterone levels between 600 ng/dL and 800 ng/dL, and semen analyses were performed at periodic intervals. In patients remaining azoospermic on semen analysis, surgical testicular biopsy and sperm extraction were performed. After clomiphene citrate therapy, 64.3% of the patients demonstrated sperm in their semen analyses ranging from 1 to 16 million sperm/mL, with a mean sperm density of 3.8 million/mL. Sufficient sperm for ICSI was retrieved by testicular sperm extraction in all patients, even though 35.7% remained azoospermic. Additionally, clomiphene citrate administration resulted in a statistically significant increase in testis biopsy patterns associated with greater likelihood of sperm obtained by surgical extraction (P < .05). We conclude that clomiphene citrate administration may result in sperm in the ejaculate of patients with nonobstructive azoospermia or the simplification of testis sperm retrieval. Surgeons may consider a course of clomiphene citrate administration prior to surgical sperm retrieval in patients with nonobstructive azoospermia.
Link to original article on pubmed

Article medical research extract:
Clomiphene increases free testosterone levels in men with both secondary hypogonadism and erectile dysfunction: who does and does not benefit?
Article published on International journal of impotence research, 2003 June 1986
Center for Sexual Function (Endocrinology), Peabody, Massachusetts 01960, USA
Secondary hypogonadism is more common than primary gonadal failure and is seen in chronic and acute illnesses. Although testosterone has a role in erections, its importance in erectile dysfunction (ED) has been controversial. Hypogonadism produced by functional suppression of pituitary gonadotropins has been shown to correct with clomiphene citrate, but with a modest effect on sexual function. We wondered if longer treatment would produce improved results. A total of 178 men with secondary hypogonadism and ED received clomiphene citrate for 4 months. Sexual function improved in 75%, with no change in 25%, while significant increases in luteinizing hormone (P<0.001) and free testosterone (P<0.001) occurred in all patients.Multivariable analysis showed that responses decreased significantly with aging (P<0.05). Decreased responses also occurred in men with diabetes, hypertension, coronary artery disease, and multiple medication use. Since these conditions are more prevalent with aging, chronic disease may be a more important determinant of sexual dysfunction. Men with anxiety-related disorders responded better to normalization of testosterone. Assessment of androgen status should be accomplished in all men with ED. For those with lower than normal age-matched levels of testosterone treatment directed at normalizing testosterone with clomiphene citrate is a viable alternative to giving androgen supplements.
Link to original article on pubmed

To summarize Clomid (Clomiphene) is known to be used for the following conditions:

  • In women as a fertility drug
  • In men with low natural testosterone production
  • In men with azoospermia, low or lack of sperm production.
  • It may be used for other conditions as determined by a doctor. You may not assume any use listed here as being the right for you without consulting with a licensed physician.


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